Name: JNJ-28312141
Rating: 5 (10 reviews)

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HIT ID:HIT212674151
Cas No:885692-52-4
常用名:JNJ-28312141
别名:JNJ28312141, JNJ 28312141
IUPAC:4-cyano-N-[2-(cyclohex-1-en-1-yl)-4-{1-[2-(dimethylamino)acetyl]piperidin-4-yl}phenyl]-1H-imidazole-2-carboxamide
IUPAC:4-cyano-N-[2-(cyclohex-1-en-1-yl)-4-{1-[2-(dimethylamino)acetyl]piperidin-4-yl}phenyl]-1H-imidazole-2-carboxamide
InChI key:GUBJNPWVIUFSTR-UHFFFAOYSA-N

分子式:C26H32N6O2
分子量:460.582
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:2.2731452
SMILES:CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:31|
SMILES:CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:31|

JNJ-28312141 is an orally active CSF1R inhibitor and a FLT3 inhibitor. JNJ-28312141 is a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.

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