Name: LY2922083
Rating: 5 (10 reviews)

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HIT ID:HIT212679695
Cas No:1309435-78-6
常用名:LY2922083
别名:LY-2922083, LY 2922083
IUPAC:(3S)-3-(4-{[5-({2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl}methyl)thiophen-2-yl]methoxy}phenyl)hex-4-ynoic acid
IUPAC:(3S)-3-(4-{[5-({2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl}methyl)thiophen-2-yl]methoxy}phenyl)hex-4-ynoic acid
InChI key:LGIUHWQDGPFXSG-VWLOTQADSA-N

分子式:C31H33NO3S
分子量:499.67
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.2587347
SMILES:CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc45)CC3)s2)cc1
SMILES:CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc45)CC3)s2)cc1

LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion.

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