Name: Tebuquine
Rating: 5 (10 reviews)

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HIT ID:HIT212680596
Cas No:74129-03-6
常用名:Tebuquine
别名:WR-228,258, WR 228,258, CI-897, CI897, CI 897
别名:WR-228,258, WR 228,258, CI-897, CI897, CI 897
IUPAC:3-[(tert-butylamino)methyl]-4'-chloro-5-[(7-chloroquinolin-4-yl)amino]-[1,1'-biphenyl]-2-ol
IUPAC:3-[(tert-butylamino)methyl]-4'-chloro-5-[(7-chloroquinolin-4-yl)amino]-[1,1'-biphenyl]-2-ol
InChI key:BCHMRNALCJISMZ-UHFFFAOYSA-N

分子式:C26H25Cl2N3O
分子量:466.41
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:5.6147738
SMILES:CC(C)(C)NCc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1O)-c1ccc(Cl)cc1
SMILES:CC(C)(C)NCc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1O)-c1ccc(Cl)cc1

Tebuquine is an antimalarial agent. Tebuquine is active against P. falciparum in vitro. Tebuquine in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from that of chloroquine. Tebuquine has no action in the CIPC in vitro and affects primarily mitochondria of the parasites in vivo. It probably acts through a metabolite. Both pre-erythrocytic and erythrocytic stages of rodent malaria parasites are affected by Tebuquine.

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