Name: BPN-15606
Rating: 5 (10 reviews)

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HIT ID:HIT212686635
Cas No:1914989-49-3
常用名:BPN-15606
IUPAC:N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-4-methylpyridazin-3-amine
IUPAC:N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-4-methylpyridazin-3-amine
InChI key:JZCREVMHGYOLRL-INIZCTEOSA-N

分子式:C23H23FN6O
分子量:418.476
氢键供体数 (HBD):1
氢键受体数 (HBA):6
LogP:4.1727853
SMILES:COc1nc(ccc1-n1cnc(C)c1)-c1cc(C)c(N[C@@H](C)c2ccc(F)cc2)nn1
SMILES:COc1nc(ccc1-n1cnc(C)c1)-c1cc(C)c(N[C@@H](C)c2ccc(F)cc2)nn1

BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance. BPN-15606 significantly lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice[1].

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