Name: (R)-JNJ-31020028
Rating: 5 (10 reviews)

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HIT ID:HIT212686674
Cas No:1094873-17-2
常用名:(R)-JNJ-31020028
IUPAC:N-(4-{4-[(R)-(diethylcarbamoyl)(phenyl)methyl]piperazin-1-yl}-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
IUPAC:N-(4-{4-[(R)-(diethylcarbamoyl)(phenyl)methyl]piperazin-1-yl}-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
InChI key:OVUNRYUVDVWTTE-JGCGQSQUSA-N

分子式:C34H36FN5O2
分子量:565.693
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:5.360987
SMILES:CCN(CC)C(=O)[C@H](N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
SMILES:CCN(CC)C(=O)[C@H](N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1

(R)-JNJ-31020028 is a high-affinity, selective brain-penetrant antagonist of the neuropeptide Y Y2 receptor, with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively.

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