Name: Aglafoline
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212686828
Cas No:143901-35-3
常用名:Aglafoline
别名:Rocaglamide U, Aglafolin, (-)-Methyl rocaglate
别名:Rocaglamide U, Aglafolin, (-)-Methyl rocaglate
IUPAC:methyl (2S,3R,4R,5S,6R)-2,3-dihydroxy-10,12-dimethoxy-6-(4-methoxyphenyl)-5-phenyl-7-oxatricyclo[6.4.0.0^{2,6}]dodeca-1(12),8,10-triene-4-carboxylate
IUPAC:methyl (2S,3R,4R,5S,6R)-2,3-dihydroxy-10,12-dimethoxy-6-(4-methoxyphenyl)-5-phenyl-7-oxatricyclo[6.4.0.0^{2,6}]dodeca-1(12),8,10-triene-4-carboxylate
InChI key:VFTGDXPPYSWBSO-GWNOIRNCSA-N

分子式:C28H28O8
分子量:492.524
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:2.894016
SMILES:COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC
SMILES:COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC

Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.

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