Name: AKT-IN-3
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT212686842
Cas No:2374740-21-1
常用名:AKT-IN-3
IUPAC:5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-[(3S,4S,6S)-4-(3,4-difluorophenyl)-6-[(methylcarbamoyl)methyl]piperidin-3-yl]furan-2-carboxamide
IUPAC:5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-[(3S,4S,6S)-4-(3,4-difluorophenyl)-6-[(methylcarbamoyl)methyl]piperidin-3-yl]furan-2-carboxamide
InChI key:SXDPQGRNHSLZPC-ZJNRKIDTSA-N

分子式:C23H23Cl2F2N5O3
分子量:526.37
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:2.1028337
SMILES:CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1
SMILES:CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1

AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK.

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