Name: AMG-548 hydrochloride (864249-60-5 free base)
Rating: 5 (10 reviews)

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HIT ID:HIT212686877
Cas No:
常用名:AMG-548 hydrochloride (864249-60-5 free base)
常用名:AMG-548 hydrochloride (864249-60-5 free base)
别名:AMG-548 hydrochloride
IUPAC:2-[(2-amino-3-phenylpropyl)amino]-3-methyl-5-(naphthalen-2-yl)-6-(pyridin-4-yl)-3,4-dihydropyrimidin-4-one hydrochloride
IUPAC:2-[(2-amino-3-phenylpropyl)amino]-3-methyl-5-(naphthalen-2-yl)-6-(pyridin-4-yl)-3,4-dihydropyrimidin-4-one hydrochloride
InChI key:OZNZBRANICIEBZ-UHFFFAOYSA-N

分子式:C29H28ClN5O
分子量:498.03
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:3.729537
SMILES:Cl.Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O
SMILES:Cl.Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O

AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).

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