Name: AR-A 2
Rating: 5 (10 reviews)

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HIT ID:HIT212686942
Cas No:220051-79-6
常用名:AR-A 2
别名:AR-A 000002
IUPAC:N-[(2R)-5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(morpholin-4-yl)benzamide
IUPAC:N-[(2R)-5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(morpholin-4-yl)benzamide
InChI key:IHDRUIHIJWCTIY-JOCHJYFZSA-N

分子式:C27H36N4O2
分子量:448.611
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:3.569
SMILES:CN1CCN(CC1)c1ccc(C)c2CC[C@H](Cc12)NC(=O)c1ccc(cc1)N1CCOCC1
SMILES:CN1CCN(CC1)c1ccc(C)c2CC[C@H](Cc12)NC(=O)c1ccc(cc1)N1CCOCC1

AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

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