AS2863619 free base | CAS 2241300-50-3 | AnyMole

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HIT212686964

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HIT212686964

HIT ID:HIT212686964
Cas No:2241300-50-3
常用名:AS2863619 free base
IUPAC:4-[1-(2-methyl-1H-1,3-benzodiazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine
IUPAC:4-[1-(2-methyl-1H-1,3-benzodiazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine
InChI key:OORKHRHPVSWORX-UHFFFAOYSA-N

分子式:C16H12N8O
分子量:332.327
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:1.0977864
SMILES:Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N
SMILES:Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N

AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.

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TargetMolSC
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5日内发货
纯度
-
¥ 1,730.00
1

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