ATM Inhibitor-1 | CAS 2135639-94-8 | AnyMole

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HIT212686981

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HIT212686981

HIT ID:HIT212686981
Cas No:2135639-94-8
常用名:ATM Inhibitor-1
IUPAC:6-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-N-methyl-4-{[(1S)-1-(oxan-4-yl)ethyl]amino}cinnoline-3-carboxamide
IUPAC:6-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-N-methyl-4-{[(1S)-1-(oxan-4-yl)ethyl]amino}cinnoline-3-carboxamide
InChI key:SJOFSBIUJPEXTG-SFHVURJKSA-N

分子式:C27H36N6O3
分子量:492.624
氢键供体数 (HBD):2
氢键受体数 (HBA):8
LogP:2.5173807
SMILES:CNC(=O)c1nnc2ccc(cc2c1N[C@@H](C)C1CCOCC1)-c1ccc(OCCCN(C)C)nc1
SMILES:CNC(=O)c1nnc2ccc(cc2c1N[C@@H](C)C1CCOCC1)-c1ccc(OCCCN(C)C)nc1

ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM).

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TargetMolSC
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货期
3-6月
纯度
-
¥ 22,200.00
1

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