Name: PF-06372222
Rating: 5 (10 reviews)

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HIT ID:HIT212689301
Cas No:1407592-99-7
常用名:PF-06372222
别名:PF-0637222, PF0637222, PF 0637222
IUPAC:3-({4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]phenyl}formamido)propanoic acid
IUPAC:3-({4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]phenyl}formamido)propanoic acid
InChI key:MYZIDYJMNWEJMC-QHCPKHFHSA-N

分子式:C26H28F3N5O3
分子量:515.537
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:3.393868
SMILES:CC1(C)CC(C1)[C@@H](Nc1ccc(nc1)-n1cnc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
SMILES:CC1(C)CC(C1)[C@@H](Nc1ccc(nc1)-n1cnc(c1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O

PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion.

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