Name: PF-06679142
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212689304
Cas No:1467059-66-0
常用名:PF-06679142
别名:PF-6679142, PF6679142, PF06679142, PF 6679142
别名:PF-6679142, PF6679142, PF06679142, PF 6679142
IUPAC:4,6-difluoro-5-{4-[(2S)-oxan-2-yl]phenyl}-1H-indole-3-carboxylic acid
IUPAC:4,6-difluoro-5-{4-[(2S)-oxan-2-yl]phenyl}-1H-indole-3-carboxylic acid
InChI key:JQJNGAWEMYQJIQ-INIZCTEOSA-N

分子式:C20H17F2NO3
分子量:357.357
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:4.4481297
SMILES:OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)[C@@H]3CCCCO3)c(F)c12
SMILES:OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)[C@@H]3CCCCO3)c(F)c12

PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.

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