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  3. HIT212689315
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HIT212689315
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HIT212689315
  • HIT ID:HIT212689315
  • Cas No:2091769-17-2
  • 常用名:Fosmanogepix
  • 别名:E1211, APX001
  • IUPAC:2-amino-1-[(hydrogen phosphonatooxy)methyl]-3-[3-({4-[(pyridin-2-yloxy)methyl]phenyl}methyl)-1,2-oxazol-5-yl]pyridin-1-ium
    IUPAC:2-amino-1-[(hydrogen phosphonatooxy)methyl]-3-[3-({4-[(pyridin-2-yloxy)methyl]phenyl}methyl)-1,2-oxazol-5-yl]pyridin-1-ium
  • InChI key:JQONJQKKVAHONF-UHFFFAOYSA-N
  • 分子式:C22H21N4O6P
  • 分子量:468.406
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):7
  • LogP:-3.539194
  • SMILES:Nc1c(ccc[n+]1COP(O)([O-])=O)-c1cc(Cc2ccc(COc3ccccn3)cc2)no1
    SMILES:Nc1c(ccc[n+]1COP(O)([O-])=O)-c1cc(Cc2ccc(COc3ccccn3)cc2)no1
  • Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
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  • 供应商
    TargetMolSC
    规格
    货期
    3-6月
    纯度
    -
    待询
    1

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