Name: SEN-1269
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT212689423
Cas No:956128-01-1
常用名:SEN-1269
IUPAC:3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol
IUPAC:3-({5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl}amino)phenol
InChI key:MFPAAKZZUIRMKR-UHFFFAOYSA-N

分子式:C18H18N4O2
分子量:322.368
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:3.473213
SMILES:CN(C)c1cccc(Oc2cnc(Nc3cccc(O)c3)nc2)c1
SMILES:CN(C)c1cccc(Oc2cnc(Nc3cccc(O)c3)nc2)c1

SEN-1269 is an amyloid-β (AB) aggregation inhibitor that acts by blocking Aβ(1-42) aggregation and protecting neuronal cell lines exposed to Aβ(1-42), reducing Aβ oligomer-induced LTP and memory deficits in vivo.

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