Name: HTH-01-091
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212689446
Cas No:2000209-42-5
常用名:HTH-01-091
别名:HTH01-091, HTH-01091, HTH 01-091, HTH 01091
别名:HTH01-091, HTH-01091, HTH 01-091, HTH 01091
IUPAC:9-(3,5-dichloro-4-hydroxyphenyl)-1-[(1r,4r)-4-[(dimethylamino)methyl]cyclohexyl]-1H,2H,3H,4H-pyrimido[5,4-c]quinolin-2-one
IUPAC:9-(3,5-dichloro-4-hydroxyphenyl)-1-[(1r,4r)-4-[(dimethylamino)methyl]cyclohexyl]-1H,2H,3H,4H-pyrimido[5,4-c]quinolin-2-one
InChI key:FUVRHGKKWNNBJX-RHDGDCLCSA-N

分子式:C26H28Cl2N4O2
分子量:499.44
氢键供体数 (HBD):2
氢键受体数 (HBA):4
LogP:3.557658
SMILES:CN(C)C[C@H]1CC[C@@H](CC1)N1C(=O)NCc2cnc3ccc(cc3c12)-c1cc(Cl)c(O)c(Cl)c1 |wU:7.10,wD:4.3,(2.1,10.11,;2.87,8.77,;4.41,8.77,;2.1,7.44,;2.87,6.1,;2.1,4.77,;2.87,3.44,;4.41,3.44,;5.18,4.77,;4.41,6.1,;5.18,2.1,;6.72,2.1,;7.49,3.44,;7.49,.77,;6.72,-.56,;5.18,-.56,;4.41,-1.9,;2.87,-1.9,;2.1,-.56,;.56,-.56,;-.21,.77,;.56,2.1,;2.1,2.1,;2.87,.77,;4.41,.77,;-.21,3.44,;-1.75,3.44,;-2.52,4.77,;-4.06,4.77,;-1.75,6.1,;-2.52,7.44,;-.21,6.1,;.56,7.44,;.56,4.77,)|
SMILES:CN(C)C[C@H]1CC[C@@H](CC1)N1C(=O)NCc2cnc3ccc(cc3c12)-c1cc(Cl)c(O)c(Cl)c1 |wU:7.10,wD:4.3,(2.1,10.11,;2.87,8.77,;4.41,8.77,;2.1,7.44,;2.87,6.1,;2.1,4.77,;2.87,3.44,;4.41,3.44,;5.18,4.77,;4.41,6.1,;5.18,2.1,;6.72,2.1,;7.49,3.44,;7.49,.77,;6.72,-.56,;5.18,-.56,;4.41,-1.9,;2.87,-1.9,;2.1,-.56,;.56,-.56,;-.21,.77,;.56,2.1,;2.1,2.1,;2.87,.77,;4.41,.77,;-.21,3.44,;-1.75,3.44,;-2.52,4.77,;-4.06,4.77,;-1.75,6.1,;-2.52,7.44,;-.21,6.1,;.56,7.44,;.56,4.77,)|

HTH-01-091 是一种强效且选择性的 maternal embryonic leucine zipper kinase (MELK) 抑制剂（IC50 ：10.5 nM）。HTH-01-091 对PIM1/2/3、RIPK2、DYRK3、smMLCK 和 CLK2有抑制作用。HTH-01-091 可用于研究乳腺癌。

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~