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  3. HIT212692180
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HIT212692180
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HIT212692180
  • HIT ID:HIT212692180
  • Cas No:908380-97-2
  • 常用名:CBS-3595
  • 别名:CBS3595
  • IUPAC:N-{4-[4-(4-fluorophenyl)-2-methanesulfinyl-1-methyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide
    IUPAC:N-{4-[4-(4-fluorophenyl)-2-methanesulfinyl-1-methyl-1H-imidazol-5-yl]pyridin-2-yl}acetamide
  • InChI key:DRMJRHUMYBYDIX-UHFFFAOYSA-N
  • 分子式:C18H17FN4O2S
  • 分子量:372.42
  • 氢键供体数 (HBD):1
  • 氢键受体数 (HBA):4
  • LogP:1.8536161
  • SMILES:CC(=O)Nc1cc(ccn1)-c1c(nc(n1C)S(C)=O)-c1ccc(F)cc1
    SMILES:CC(=O)Nc1cc(ccn1)-c1c(nc(n1C)S(C)=O)-c1ccc(F)cc1
  • CBS-3595 is a potent and dual Inhibitor of p38α MAPK/PDE-4 with a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38α MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic properties and low plasma protein binding contributing to the outstanding results of the efficacy experiments performed in animal models and humans. The inhibition of TNFα release was achieved at dose levels and systemic concentrations that were well below levels related to toxicity.
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 11,700.00
    1

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