Name: MGS-0039
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT212693070
Cas No:569686-87-9
常用名:MGS-0039
别名:MGS0039, BCI-632, BCI632, BCI 632
IUPAC:(1R,2R,3R,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
IUPAC:(1R,2R,3R,5R,6R)-2-amino-3-[(3,4-dichlorophenyl)methoxy]-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
InChI key:LFAGGDAZZKUVKO-JAGWWQSPSA-N

分子式:C15H14Cl2FNO5
分子量:378.18
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:-0.39513376
SMILES:[H][C@@]12C[C@@H](OCc3ccc(Cl)c(Cl)c3)[C@@](N)(C(O)=O)[C@]1([H])[C@@]2(F)C(O)=O
SMILES:[H][C@@]12C[C@@H](OCc3ccc(Cl)c(Cl)c3)[C@@](N)(C(O)=O)[C@]1([H])[C@@]2(F)C(O)=O

MGS-0039 is a group II metabotropic glutamate receptor (mgluR2/3) antagonist. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the antidepressant-like action of these compounds. Dopamine release in the NAc shell is regulated by mGlu 2/3 receptors.

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