Name: MIPS-9922
Rating: 5 (10 reviews)

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HIT ID:HIT212693080
Cas No:1416956-33-6
常用名:MIPS-9922
IUPAC:(2S)-2-amino-1-(4-{4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-3-phenylpropan-1-one
IUPAC:(2S)-2-amino-1-(4-{4-[2-(difluoromethyl)-1H-1,3-benzodiazol-1-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-3-phenylpropan-1-one
InChI key:VOPWCDJBVPMVLJ-FQEVSTJZSA-N

分子式:C28H31F2N9O2
分子量:563.614
氢键供体数 (HBD):1
氢键受体数 (HBA):9
LogP:3.9702835
SMILES:N[C@@H](Cc1ccccc1)C(=O)N1CCN(CC1)c1nc(nc(n1)-n1c(nc2ccccc12)C(F)F)N1CCOCC1
SMILES:N[C@@H](Cc1ccccc1)C(=O)N1CCN(CC1)c1nc(nc(n1)-n1c(nc2ccccc12)C(F)F)N1CCOCC1

MIPS-9922 is a potent and selective PI3Kβ inhibitor with antiplatelet activity. MIPS-9922 inhibited integrin αIIbβ3 activation and αIIbβ3 dependent platelet adhesion to immobilized vWF under high shear. MIPS-9922 also potently inhibited ADP-induced washed platelet aggregation.

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