Name: NCG21
Rating: 5 (10 reviews)

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HIT ID:HIT212693165
Cas No:1079821-35-4
常用名:NCG21
别名:NCG-21, NCG 21
IUPAC:4-(4-{2-[phenyl(pyridin-2-yl)amino]ethoxy}phenyl)butanoic acid
IUPAC:4-(4-{2-[phenyl(pyridin-2-yl)amino]ethoxy}phenyl)butanoic acid
InChI key:WQXHZCYCKCQFQP-UHFFFAOYSA-N

分子式:C23H24N2O3
分子量:376.456
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:3.9763298
SMILES:OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1
SMILES:OC(=O)CCCc1ccc(OCCN(c2ccccc2)c2ccccn2)cc1

NCG21 is a GPR120 agonist, which showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that express GPR120 endogenously. Administration of NCG21 into the mouse colon caused an increase in plasma GLP-1 levels.

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