Name: Nerispirdine HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212693184
Cas No:119229-64-0
常用名:Nerispirdine HCl
别名:Nerispirdine hydrochloride, HP-184, HP184, HP 184
别名:Nerispirdine hydrochloride, HP-184, HP184, HP 184
IUPAC:N-(3-fluoropyridin-4-yl)-3-methyl-N-propyl-1H-indol-1-amine hydrochloride
IUPAC:N-(3-fluoropyridin-4-yl)-3-methyl-N-propyl-1H-indol-1-amine hydrochloride
InChI key:FYIIKHJFVLTAFI-UHFFFAOYSA-N

分子式:C17H19ClFN3
分子量:319.81
氢键供体数 (HBD):0
氢键受体数 (HBA):2
LogP:3.869785
SMILES:Cl.CCCN(c1ccncc1F)n1cc(C)c2ccccc12
SMILES:Cl.CCCN(c1ccncc1F)n1cc(C)c2ccccc12

Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a -70 mV holding potential. Nerispirdine also inhibits K(v)1.1 and K(v)1.2 with IC(50) values of 3.6 and 3.7 micromol/L, respectively.

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