Name: CB 300919
Rating: 5 (10 reviews)

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HIT ID:HIT212708371
Cas No:289715-28-2
常用名:CB 300919
IUPAC:4-[({7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxo-3,4-dihydroquinazolin-6-yl}methyl)(prop-2-yn-1-yl)amino]-N-[(pyridin-3-yl)methyl]benzamide
IUPAC:4-[({7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxo-3,4-dihydroquinazolin-6-yl}methyl)(prop-2-yn-1-yl)amino]-N-[(pyridin-3-yl)methyl]benzamide
InChI key:LWTCFUSGPRGUBX-UHFFFAOYSA-N

分子式:C32H34ClN7O2
分子量:584.12
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:2.9814963
SMILES:CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4cccnc4)cc3c(=O)n2C)CC1
SMILES:CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4cccnc4)cc3c(=O)n2C)CC1

CB 300919 is a quinazoline-based antitumor agent with high activity in the CH1 human ovarian tumor xenograft and has continuous exposure (96 h) growth inhibition (IC50: 2 nM).

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