Name: CC0651
Rating: 5 (10 reviews)

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HIT ID:HIT212708382
Cas No:1319207-44-7
常用名:CC0651
别名:CC-0651
IUPAC:(2R,3S,4S)-5-{3',5'-dichloro-[1,1'-biphenyl]-4-yl}-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
IUPAC:(2R,3S,4S)-5-{3',5'-dichloro-[1,1'-biphenyl]-4-yl}-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
InChI key:NTCBTNCWNRCBGX-YTQUADARSA-N

分子式:C20H21Cl2NO6
分子量:442.29
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:2.316985
SMILES:COCC(=O)N[C@@H](Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1)[C@H](O)[C@@H](O)C(O)=O
SMILES:COCC(=O)N[C@@H](Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1)[C@H](O)[C@@H](O)C(O)=O

CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM) by blocking ubiquitin transfer to substrates, for use in cancer research.

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