Name: CH-0793076
Rating: 5 (10 reviews)

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HIT ID:HIT212708412
Cas No:534605-78-2
常用名:CH-0793076
别名:TP3076
IUPAC:(10S)-10-ethyl-10-hydroxy-23-pentyl-8-oxa-4,15,21,23-tetraazahexacyclo[14.7.1.0^{2,14}.0^{4,13}.0^{6,11}.0^{20,24}]tetracosa-1(24),2(14),6(11),12,15,17,19,21-octaene-5,9-dione
IUPAC:(10S)-10-ethyl-10-hydroxy-23-pentyl-8-oxa-4,15,21,23-tetraazahexacyclo[14.7.1.0^{2,14}.0^{4,13}.0^{6,11}.0^{20,24}]tetracosa-1(24),2(14),6(11),12,15,17,19,21-octaene-5,9-dione
InChI key:NPAAFPODGAKMTC-SANMLTNESA-N

分子式:C26H26N4O4
分子量:458.518
氢键供体数 (HBD):1
氢键受体数 (HBA):6
LogP:2.4371681
SMILES:CCCCCn1cnc2cccc3nc-4c(Cn5c-4cc4c(COC(=O)[C@]4(O)CC)c5=O)c1c23
SMILES:CCCCCn1cnc2cccc3nc-4c(Cn5c-4cc4c(COC(=O)[C@]4(O)CC)c5=O)c1c23

CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM).

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