Name: Momelotinib Mesylate
Rating: 5 (10 reviews)

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HIT ID:HIT212708481
Cas No:1056636-07-7
常用名:Momelotinib Mesylate
别名:CYT387 (Mesylate)
IUPAC:N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide; methanesulfonic acid
IUPAC:N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide; methanesulfonic acid
InChI key:LYIDPXWFFVJQLY-UHFFFAOYSA-N

分子式:C24H26N6O5S
分子量:510.57
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:2.701315
SMILES:CS(O)(=O)=O.O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
SMILES:CS(O)(=O)=O.O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.

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