Name: DT-061
Rating: 5 (10 reviews)

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HIT ID:HIT212708547
Cas No:1809427-19-7
常用名:DT-061
IUPAC:N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide
IUPAC:N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide
InChI key:WGKGADVPRVLHHZ-ZHRMCQFGSA-N

分子式:C25H23F3N2O5S
分子量:520.52
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:5.565994
SMILES:O[C@H]1[C@@H](CCC[C@@H]1N1c2ccccc2Oc2ccccc12)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
SMILES:O[C@H]1[C@@H](CCC[C@@H]1N1c2ccccc2Oc2ccccc12)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1

DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

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