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  3. HIT212708586
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HIT212708586
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HIT212708586
  • HIT ID:HIT212708586
  • Cas No:1403255-00-4
  • 常用名:Tazemetostat trihydrochloride
  • 别名:EPZ-6438 trihydrochloride, E-7438 trihydrochloride
    别名:EPZ-6438 trihydrochloride, E-7438 trihydrochloride
  • IUPAC:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-[ethyl(oxan-4-yl)amino]-4-methyl-4'-[(morpholin-4-yl)methyl]-[1,1'-biphenyl]-3-carboxamide trihydrochloride
    IUPAC:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-[ethyl(oxan-4-yl)amino]-4-methyl-4'-[(morpholin-4-yl)methyl]-[1,1'-biphenyl]-3-carboxamide trihydrochloride
  • InChI key:PBAHJOUNGPCAIP-UHFFFAOYSA-N
  • 分子式:C34H47Cl3N4O4
  • 分子量:682.12
  • 氢键供体数 (HBD):2
  • 氢键受体数 (HBA):6
  • LogP:3.4527955
  • SMILES:Cl.Cl.Cl.CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
    SMILES:Cl.Cl.Cl.CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
  • Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay).
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    2-4周
    纯度
    -
    ¥ 11,350.00
    1

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