Name: FTI-2153
Rating: 5 (10 reviews)

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HIT ID:HIT212708637
Cas No:344900-92-1
常用名:FTI-2153
IUPAC:methyl (2S)-2-{[5-({[(1H-imidazol-5-yl)methyl]amino}methyl)-2'-methyl-[1,1'-biphenyl]-2-yl]formamido}-4-(methylsulfanyl)butanoate
IUPAC:methyl (2S)-2-{[5-({[(1H-imidazol-5-yl)methyl]amino}methyl)-2'-methyl-[1,1'-biphenyl]-2-yl]formamido}-4-(methylsulfanyl)butanoate
InChI key:KZCMMZOLCBZLNG-QHCPKHFHSA-N

分子式:C25H30N4O3S
分子量:466.6
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:3.136632
SMILES:COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C
SMILES:COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C

FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing.

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