Name: (3R,5S)-Fluvastatin
Rating: 5 (10 reviews)

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HIT ID:HIT212708742
Cas No:93957-54-1;155229-75-7
常用名:(3R,5S)-Fluvastatin
别名:(3R,5S)-XU 62-320 free acid, (3R,5S)-Fluvastatin
别名:(3R,5S)-XU 62-320 free acid, (3R,5S)-Fluvastatin
IUPAC:(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
IUPAC:(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
InChI key:FJLGEFLZQAZZCD-MCBHFWOFSA-N

分子式:C24H26FNO4
分子量:411.473
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:3.8259492
SMILES:CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)c(-c2ccc(F)cc2)c2ccccc12
SMILES:CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)c(-c2ccc(F)cc2)c2ccccc12

(3R,5S)-Fluvastatin, the 3R,5S-isomer of Fluvastatin (XU 62-320 free acid), stands as the inaugural fully synthetic, competitive inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It safeguards vascular smooth muscle cells from oxidative stress by activating the Nrf2-dependent antioxidant pathway.

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