Name: (±)-AMG 487
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212708784
Cas No:
常用名:(±)-AMG 487
IUPAC:N-{1-[3-(4-ethoxyphenyl)-4-oxo-3H,4H-pyrido[2,3-d]pyrimidin-2-yl]ethyl}-N-[(pyridin-3-yl)methyl]-2-[4-(trifluoromethoxy)phenyl]acetamide
IUPAC:N-{1-[3-(4-ethoxyphenyl)-4-oxo-3H,4H-pyrido[2,3-d]pyrimidin-2-yl]ethyl}-N-[(pyridin-3-yl)methyl]-2-[4-(trifluoromethoxy)phenyl]acetamide
InChI key:WQTKNBPCJKRYPA-UHFFFAOYSA-N

分子式:C32H28F3N5O4
分子量:603.602
氢键供体数 (HBD):0
氢键受体数 (HBA):7
LogP:5.690406
SMILES:CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)C(C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1
SMILES:CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)C(C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1

AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).

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