Name: Prothrombin (474-477) [Mus musculus]
Rating: 5 (10 reviews)

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HIT ID:HIT212708936
Cas No:
常用名:Prothrombin (474-477) [Mus musculus]
常用名:Prothrombin (474-477) [Mus musculus]
IUPAC:(2R)-1-{2-[(2S,3R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl}pyrrolidine-2-carboxylic acid
IUPAC:(2R)-1-{2-[(2S,3R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl}pyrrolidine-2-carboxylic acid
InChI key:FMFPZBKYTSVNCQ-HBLKAAFGSA-N

分子式:C26H36N6O6
分子量:528.61
氢键供体数 (HBD):6
氢键受体数 (HBA):8
LogP:-1.9125245
SMILES:[H][C@@]1(CCCN1C(=O)C(Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@H](C)CC)C(O)=O
SMILES:[H][C@@]1(CCCN1C(=O)C(Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@H](C)CC)C(O)=O

Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the stemming of blood loss.

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