Name: CP-471474
Rating: 5 (10 reviews)

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HIT ID:HIT212708942
Cas No:210755-45-6
常用名:CP-471474
别名:CP 471474
IUPAC:2-[4-(4-fluorophenoxy)benzenesulfonamido]-N-hydroxy-2-methylpropanamide
IUPAC:2-[4-(4-fluorophenoxy)benzenesulfonamido]-N-hydroxy-2-methylpropanamide
InChI key:QCOQJYRPDUMCNP-UHFFFAOYSA-N

分子式:C16H17FN2O5S
分子量:368.38
氢键供体数 (HBD):3
氢键受体数 (HBA):4
LogP:2.115331
SMILES:CC(C)(NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NO
SMILES:CC(C)(NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NO

Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.

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