Name: DL-threo dihydrosphingosine
Rating: 5 (10 reviews)

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HIT ID:HIT212708968
Cas No:15639-50-6;2304-75-8
常用名:DL-threo dihydrosphingosine
别名:DTD, DL-Safingol, DL threo dihydrosphingosine
别名:DTD, DL-Safingol, DL threo dihydrosphingosine
IUPAC:(2S,3S)-2-aminooctadecane-1,3-diol
IUPAC:(2S,3S)-2-aminooctadecane-1,3-diol
InChI key:OTKJDMGTUTTYMP-ROUUACIJSA-N

分子式:C18H39NO2
分子量:301.515
氢键供体数 (HBD):3
氢键受体数 (HBA):3
LogP:4.7725945
SMILES:CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO
SMILES:CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO

DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo dihydrosphingosine may be usefully employed to block smooth muscle cell proliferation.

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