Name: Tedizolid HCl (856866-72-3 free base)
Rating: 5 (10 reviews)

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HIT ID:HIT212709379
Cas No:
常用名:Tedizolid HCl (856866-72-3 free base)
常用名:Tedizolid HCl (856866-72-3 free base)
别名:Tedizolid HCl
IUPAC:(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one hydrochloride
IUPAC:(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one hydrochloride
InChI key:NSRWOCXBPMXXLU-UTONKHPSSA-N

分子式:C17H16ClFN6O3
分子量:406.8
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:2.1188114
SMILES:Cl.Cn1nnc(n1)-c1ccc(cn1)-c1ccc(cc1F)N1C[C@H](CO)OC1=O
SMILES:Cl.Cn1nnc(n1)-c1ccc(cn1)-c1ccc(cc1F)N1C[C@H](CO)OC1=O

Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially available oxazolidinone antibiotic and is the prodrug form of tedizolid with a fixed once-daily dose. As an expanded-spectrum oxazolidinone, it has potent activity against a wide range of Gram-positive pathogens.

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