Name: Amyloid Precursor C-Terminal Peptide
Rating: 5 (10 reviews)

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HIT ID:HIT212709470
Cas No:
常用名:Amyloid Precursor C-Terminal Peptide
常用名:Amyloid Precursor C-Terminal Peptide
别名:淀粉样蛋白片段
IUPAC:(4S)-4-[(2S)-2-[(2R)-2-[(2S)-6-amino-2-[(2S)-2-[(2S,3S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-(2-aminoacetamido)-3-(4-hydroxyphenyl)propanamido]-4-carboxybutanamido]-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}-3-hydroxybutanamido]-3-(4-hydroxyphenyl)propanamido]hexanamido]-3-phenylpropanamido]-3-phenylpropanamido]-4-{[(1S)-3-carbamoyl-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{[(1S)-2-carbamoyl-1-carboxyethyl]carbamoyl}propyl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}propyl]carbamoyl}butanoic acid
IUPAC:(4S)-4-[(2S)-2-[(2R)-2-[(2S)-6-amino-2-[(2S)-2-[(2S,3S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-(2-aminoacetamido)-3-(4-hydroxyphenyl)propanamido]-4-carboxybutanamido]-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}-3-hydroxybutanamido]-3-(4-hydroxyphenyl)propanamido]hexanamido]-3-phenylpropanamido]-3-phenylpropanamido]-4-{[(1S)-3-carbamoyl-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{[(1S)-2-carbamoyl-1-carboxyethyl]carbamoyl}propyl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}propyl]carbamoyl}butanoic acid
InChI key:IBDVVBQJVQLBET-YOOHUGCYSA-N

分子式:C86H118N20O27S
分子量:1896.06
氢键供体数 (HBD):25
氢键受体数 (HBA):29
LogP:-13.308395
SMILES:[H][C@@](C)(O)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)CN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(O)=O
SMILES:[H][C@@](C)(O)[C@]([H])(NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]([H])(CCC(O)=O)NC(=O)[C@]([H])(Cc1ccc(O)cc1)NC(=O)CN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(O)=O

Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. So it is a possible contributor to Alzheimer′s pathogenesis through MAPKs- and NF-κB-dependent astrocytosis.

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