Name: Lamin fragment
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212709472
Cas No:
常用名:Lamin fragment
IUPAC:2-[2-(2-{2-[2-(4-carbamoyl-2-{2-[2-(2,6-diaminohexanamido)propanamido]acetamido}butanamido)-3-methylbutanamido]-3-methylbutanamido}-3-hydroxybutanamido)-3-methylpentanamido]-3-(1H-indol-3-yl)propanoic acid
IUPAC:2-[2-(2-{2-[2-(4-carbamoyl-2-{2-[2-(2,6-diaminohexanamido)propanamido]acetamido}butanamido)-3-methylbutanamido]-3-methylbutanamido}-3-hydroxybutanamido)-3-methylpentanamido]-3-(1H-indol-3-yl)propanoic acid
InChI key:HVMLOFRAVVEONZ-UHFFFAOYSA-N

分子式:C47H76N12O12
分子量:1001.197
氢键供体数 (HBD):14
氢键受体数 (HBA):14
LogP:-4.840255
SMILES:CCC(C)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(C)NC(=O)C(N)CCCCN)C(C)C)C(C)C)C(C)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(O)=O
SMILES:CCC(C)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(C)NC(=O)C(N)CCCCN)C(C)C)C(C)C)C(C)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(O)=O

Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amino acid sequence. Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted pattern. Lamins also play roles in DNA replication, chromatin organization, the spatial arrangement of nuclear pore complexes, nuclear growth, and anchorage of nuclear envelope proteins.

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