Name: tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
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HIT ID:HIT212709544
Cas No:
常用名:tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
常用名:tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
IUPAC:4-{[5-amino-1-({3-carboxy-1-[(1-carboxy-2-methylpropyl)carbamoyl]propyl}carbamoyl)pentyl]carbamoyl}-4-[(1-{2-[2-(2-{2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido}-3-(1H-imidazol-5-yl)propanamido)-3-methylbutanamido]-4-carboxybutanoyl}pyrrolidin-2-yl)formamido]butanoic acid
IUPAC:4-{[5-amino-1-({3-carboxy-1-[(1-carboxy-2-methylpropyl)carbamoyl]propyl}carbamoyl)pentyl]carbamoyl}-4-[(1-{2-[2-(2-{2-[2-amino-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido}-3-(1H-imidazol-5-yl)propanamido)-3-methylbutanamido]-4-carboxybutanoyl}pyrrolidin-2-yl)formamido]butanoic acid
InChI key:UXACOKSUEHOCCM-UHFFFAOYSA-N

分子式:C57H87N13O18
分子量:1242.396
氢键供体数 (HBD):16
氢键受体数 (HBA):21
LogP:-8.361971
SMILES:CC(C)CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)C)C(O)=O
SMILES:CC(C)CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)C)C(O)=O

Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent transcription5. Interestingly, the COOH terminus of 53BP1 contains tandem BRCA1 COOH terminus (BRCT) motifs.

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