Name: GSK 189254 HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212709545
Cas No:945493-87-8
常用名:GSK 189254 HCl
别名:GSK-189254A, GSK189254A, GSK 189254A, GSK 189254 hydrochloride
别名:GSK-189254A, GSK189254A, GSK 189254A, GSK 189254 hydrochloride
IUPAC:6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide hydrochloride
IUPAC:6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide hydrochloride
InChI key:GRQVZNMSXFEEHD-UHFFFAOYSA-N

分子式:C21H26ClN3O2
分子量:387.91
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:3.1047142
SMILES:Cl.CNC(=O)c1ccc(Oc2ccc3CCN(CCc3c2)C2CCC2)nc1
SMILES:Cl.CNC(=O)c1ccc(Oc2ccc3CCN(CCc3c2)C2CCC2)nc1

GSK 189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy. Histamine H3 receptor antagonists have been shown to increase the release of neurotransmitters in the brain and to enhance cognition in vivo. The compound may also be useful in the treatment of dementia and neuropathic pain.

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