Name: PD 109488
Rating: 5 (10 reviews)

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HIT ID:HIT212709547
Cas No:103733-49-9
常用名:PD 109488
别名:Quinapril Diketopiperazine, PD-109488, PD109488
别名:Quinapril Diketopiperazine, PD-109488, PD109488
IUPAC:ethyl (2S)-2-[(3S,11aS)-3-methyl-1,4-dioxo-1H,2H,3H,4H,6H,11H,11aH-pyrazino[1,2-b]isoquinolin-2-yl]-4-phenylbutanoate
IUPAC:ethyl (2S)-2-[(3S,11aS)-3-methyl-1,4-dioxo-1H,2H,3H,4H,6H,11H,11aH-pyrazino[1,2-b]isoquinolin-2-yl]-4-phenylbutanoate
InChI key:NDDYKENLGBOEPD-HSQYWUDLSA-N

分子式:C25H28N2O4
分子量:420.509
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:3.4322124
SMILES:[H][C@@]12Cc3ccccc3CN1C(=O)[C@H](C)N([C@@H](CCc1ccccc1)C(=O)OCC)C2=O
SMILES:[H][C@@]12Cc3ccccc3CN1C(=O)[C@H](C)N([C@@H](CCc1ccccc1)C(=O)OCC)C2=O

PD 109488 is a metabolite of quinapril and is a derivative of Quinapril that acts as an ACE inhibitor. Inhibition of ACE prevents the conversion of signaling peptide angiotensin I into angiotensin II, which acts as a potent vasoconstrictor. Reduced levels of angiotensin II also reduces the amount of aldosterone that is expressed due to RAAS signaling.

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