Name: Edoxaban M4
Rating: 5 (10 reviews)

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HIT ID:HIT212709701
Cas No:834919-19-6
常用名:Edoxaban M4
别名:UNII-IV344R972X, Edoxaban 4-Carboxylic Acid, D21-2393, D21 2393
别名:UNII-IV344R972X, Edoxaban 4-Carboxylic Acid, D21-2393, D21 2393
IUPAC:(1S,3R,4S)-4-{[(5-chloropyridin-2-yl)carbamoyl]formamido}-3-{5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-amido}cyclohexane-1-carboxylic acid
IUPAC:(1S,3R,4S)-4-{[(5-chloropyridin-2-yl)carbamoyl]formamido}-3-{5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-amido}cyclohexane-1-carboxylic acid
InChI key:QPYMJNYAASVNAP-CORIIIEPSA-N

分子式:C22H25ClN6O5S
分子量:520.99
氢键供体数 (HBD):4
氢键受体数 (HBA):8
LogP:-1.3296971
SMILES:CN1CCc2nc(sc2C1)C(=O)N[C@@H]1C[C@H](CC[C@@H]1NC(=O)C(=O)Nc1ccc(Cl)cn1)C(O)=O
SMILES:CN1CCc2nc(sc2C1)C(=O)N[C@@H]1C[C@H](CC[C@@H]1NC(=O)C(=O)Nc1ccc(Cl)cn1)C(O)=O

D21-2393 subjects received a single-oral-dose of edoxaban 30-90 mg in each study occasion under fasting condition. Serial blood samples were collected to measure the plasma concentrations of edoxaban and its major active metabolite D21-2393. Meanwhile, PT, INR, aPTT were measured pre- and post-dose.

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