Name: VUF-10497
Rating: 5 (10 reviews)

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HIT ID:HIT212709765
Cas No:1080623-12-6
常用名:VUF-10497
IUPAC:6-chloro-2-(4-methylpiperazin-1-yl)-N-[(thiophen-2-yl)methyl]quinazolin-4-amine
IUPAC:6-chloro-2-(4-methylpiperazin-1-yl)-N-[(thiophen-2-yl)methyl]quinazolin-4-amine
InChI key:OLJSGKYQYTWQNJ-UHFFFAOYSA-N

分子式:C18H20ClN5S
分子量:373.9
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:4.3676467
SMILES:CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1
SMILES:CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1

VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. VUF-10497 also possesses a considerable affinity for the human histamine H1 receptor.

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