Name: Hh-Ag1.5
Rating: 5 (10 reviews)

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HIT ID:HIT212709781
Cas No:612542-14-0
常用名:Hh-Ag1.5
别名:SAG-1.5, SAG1.5, SAG 1.5
IUPAC:3-chloro-4,7-difluoro-N-{[3-(pyridin-4-yl)phenyl]methyl}-N-[(1r,4r)-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide
IUPAC:3-chloro-4,7-difluoro-N-{[3-(pyridin-4-yl)phenyl]methyl}-N-[(1r,4r)-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide
InChI key:RXZDWPYJFCAZCW-MEMLXQNLSA-N

分子式:C28H26ClF2N3OS
分子量:526.04
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:6.0614276
SMILES:CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl |wU:5.8,wD:2.1,(1.22,-9.3,;1.99,-7.97,;1.22,-6.64,;1.99,-5.3,;1.22,-3.97,;-.32,-3.97,;-1.09,-5.3,;-.32,-6.64,;-1.09,-2.64,;-2.63,-2.64,;-3.4,-3.97,;-2.63,-5.3,;-3.4,-6.64,;-4.94,-6.64,;-5.71,-5.3,;-4.94,-3.97,;-7.25,-5.3,;-8.02,-6.64,;-9.56,-6.64,;-10.33,-5.3,;-9.56,-3.97,;-8.02,-3.97,;-.32,-1.3,;-1.09,.03,;1.22,-1.3,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;4.92,-4.38,;6.26,-2.07,;6.26,-.53,;4.92,.24,;4.92,1.78,;3.59,-.53,;2.13,-.06,;1.65,1.41,)|
SMILES:CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl |wU:5.8,wD:2.1,(1.22,-9.3,;1.99,-7.97,;1.22,-6.64,;1.99,-5.3,;1.22,-3.97,;-.32,-3.97,;-1.09,-5.3,;-.32,-6.64,;-1.09,-2.64,;-2.63,-2.64,;-3.4,-3.97,;-2.63,-5.3,;-3.4,-6.64,;-4.94,-6.64,;-5.71,-5.3,;-4.94,-3.97,;-7.25,-5.3,;-8.02,-6.64,;-9.56,-6.64,;-10.33,-5.3,;-9.56,-3.97,;-8.02,-3.97,;-.32,-1.3,;-1.09,.03,;1.22,-1.3,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;4.92,-4.38,;6.26,-2.07,;6.26,-.53,;4.92,.24,;4.92,1.78,;3.59,-.53,;2.13,-.06,;1.65,1.41,)|

Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50： 1 nM)和Smoothened (Smo)受体激动剂，对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。

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