Name: Deacylcortivazol
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT212709826
Cas No:4906-84-7
常用名:Deacylcortivazol
别名:UNII-3JO09QT49F, NSC 325316, DAC
IUPAC:1-[(1S,2R,13S,14S,16R,17R,18S,20S)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9,11-tetraen-17-yl]-2-hydroxyethan-1-one
IUPAC:1-[(1S,2R,13S,14S,16R,17R,18S,20S)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9,11-tetraen-17-yl]-2-hydroxyethan-1-one
InChI key:FKAINCOIINXAOK-UFVJYOHBSA-N

分子式:C30H36N2O4
分子量:488.628
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:3.187659
SMILES:C[C@@H]1C[C@H]2[C@@H]3C=C(C)C4=Cc5c(C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO)cnn5-c1ccccc1 |t:5,8|
SMILES:C[C@@H]1C[C@H]2[C@@H]3C=C(C)C4=Cc5c(C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO)cnn5-c1ccccc1 |t:5,8|

Deacylcortivazol (DAC) is a potent glucocorticoid. When incubated with glucocorticoid-resistant mutants derived from the glucocorticoid-sensitive human leukemic cell line CEM-C7, DAC caused significant growth inhibition. The cytotoxicity of DAC at concentrations higher than necessary for glucocorticoid receptor saturation is not mediated by glucocorticoid receptors.

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