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  3. HIT212710643
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HIT212710643
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HIT212710643
  • HIT ID:HIT212710643
  • Cas No:1320211-69-5
  • 常用名:Pralatrexate, (S)-
  • IUPAC:(2S)-2-({4-[(2S)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid
    IUPAC:(2S)-2-({4-[(2S)-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid
  • InChI key:OGSBUKJUDHAQEA-HOCLYGCPSA-N
  • 分子式:C23H23N7O5
  • 分子量:477.481
  • 氢键供体数 (HBD):5
  • 氢键受体数 (HBA):11
  • LogP:0.61516607
  • SMILES:Nc1nc(N)c2nc(C[C@H](CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
    SMILES:Nc1nc(N)c2nc(C[C@H](CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
  • Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.
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  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 10,600.00
    1

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