Name: NSC-670224
Rating: 5 (10 reviews)

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HIT ID:HIT212710798
Cas No:1374648-47-1
常用名:NSC-670224
别名:NSC 670224
IUPAC:dimethyl(2-{[(1s,4s)-4-tert-butyl-1-[(2,4-dichlorophenyl)methyl]cyclohexyl]oxy}ethyl)amine hydrochloride
IUPAC:dimethyl(2-{[(1s,4s)-4-tert-butyl-1-[(2,4-dichlorophenyl)methyl]cyclohexyl]oxy}ethyl)amine hydrochloride
InChI key:FSIBYCVOFLVKGN-COQUQOPOSA-N

分子式:C21H34Cl3NO
分子量:422.86
氢键供体数 (HBD):0
氢键受体数 (HBA):2
LogP:6.406111
SMILES:Cl.CN(C)CCO[C@]1(Cc2ccc(Cl)cc2Cl)CC[C@@H](CC1)C(C)(C)C |wU:7.5,19.22,wD:7.6,(9.96,,;-7.26,-1.03,;-5.92,-.26,;-5.92,1.28,;-4.59,-1.03,;-3.26,-.26,;-1.92,-1.03,;-.59,-.26,;-.06,-1.71,;1.45,-1.98,;2.44,-.8,;3.96,-1.06,;4.49,-2.51,;6,-2.78,;3.5,-3.69,;1.98,-3.42,;.99,-4.6,;.93,.01,;1.45,1.45,;.46,2.63,;-1.05,2.37,;-1.58,.92,;.99,4.08,;1.52,5.53,;2.44,3.55,;-.46,4.61,)|
SMILES:Cl.CN(C)CCO[C@]1(Cc2ccc(Cl)cc2Cl)CC[C@@H](CC1)C(C)(C)C |wU:7.5,19.22,wD:7.6,(9.96,,;-7.26,-1.03,;-5.92,-.26,;-5.92,1.28,;-4.59,-1.03,;-3.26,-.26,;-1.92,-1.03,;-.59,-.26,;-.06,-1.71,;1.45,-1.98,;2.44,-.8,;3.96,-1.06,;4.49,-2.51,;6,-2.78,;3.5,-3.69,;1.98,-3.42,;.99,-4.6,;.93,.01,;1.45,1.45,;.46,2.63,;-1.05,2.37,;-1.58,.92,;.99,4.08,;1.52,5.53,;2.44,3.55,;-.46,4.61,)|

NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen.

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