Name: Lorcainide hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212710986
Cas No:58934-46-6
常用名:Lorcainide hydrochloride
别名:Ro 13-1042, R 15889, Lorcainide HCl, Lopantrol, EINECS 261-504-6
别名:Ro 13-1042, R 15889, Lorcainide HCl, Lopantrol, EINECS 261-504-6
IUPAC:N-(4-chlorophenyl)-2-phenyl-N-[1-(propan-2-yl)piperidin-4-yl]acetamide hydrochloride
IUPAC:N-(4-chlorophenyl)-2-phenyl-N-[1-(propan-2-yl)piperidin-4-yl]acetamide hydrochloride
InChI key:FSFSWNBDCJVFGI-UHFFFAOYSA-N

分子式:C22H28Cl2N2O
分子量:407.38
氢键供体数 (HBD):0
氢键受体数 (HBA):2
LogP:4.313596
SMILES:Cl.CC(C)N1CCC(CC1)N(C(=O)Cc1ccccc1)c1ccc(Cl)cc1
SMILES:Cl.CC(C)N1CCC(CC1)N(C(=O)Cc1ccccc1)c1ccc(Cl)cc1

Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppressing reentry phenomena and ectopic pacemaker activity, especially in the ventricles.

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