Name: Liarozole HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212711629
Cas No:145858-50-0
常用名:Liarozole HCl
别名:R-75251, R75251, R 75251, Liarozole hydrochloride
别名:R-75251, R75251, R 75251, Liarozole hydrochloride
IUPAC:5-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-1,3-benzodiazole hydrochloride
IUPAC:5-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-1,3-benzodiazole hydrochloride
InChI key:OTSZCHORPMQCBZ-UHFFFAOYSA-N

分子式:C17H14Cl2N4
分子量:345.23
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:3.477468
SMILES:Cl.Clc1cccc(c1)C(c1ccc2[nH]cnc2c1)n1ccnc1
SMILES:Cl.Clc1cccc(c1)C(c1ccc2[nH]cnc2c1)n1ccnc1

Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. It also inhibits aromatase.

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