Name: Fenebrutinib HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212711749
Cas No:2128304-54-9
常用名:Fenebrutinib HCl
别名:RG-7845, RG7845, RG 7845, GDC-0853, GDC0853, GDC 0853
别名:RG-7845, RG7845, RG 7845, GDC-0853, GDC0853, GDC 0853
IUPAC:10-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl]-4,4-dimethyl-1,10-diazatricyclo[6.4.0.0^{2,6}]dodeca-2(6),7-dien-9-one hydrochloride
IUPAC:10-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl]-4,4-dimethyl-1,10-diazatricyclo[6.4.0.0^{2,6}]dodeca-2(6),7-dien-9-one hydrochloride
InChI key:UFNQEETXQCTBNF-BQAIUKQQSA-N

分子式:C37H45ClN8O4
分子量:701.27
氢键供体数 (HBD):2
氢键受体数 (HBA):9
LogP:2.5099723
SMILES:Cl.C[C@H]1CN(CCN1c1ccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1)C1COC1
SMILES:Cl.C[C@H]1CN(CCN1c1ccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1)C1COC1

Fenebrutinib is orally available inhibitor of Bruton's tyrosine kinase (BTK) with antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, leading to the inhibition of the growth of malignant B-cells that overexpress BTK.

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