Name: Azeliragon HCl
Rating: 5 (10 reviews)

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HIT ID:HIT212711785
Cas No:1284150-65-7
常用名:Azeliragon HCl
别名:TTP488 HCl, TTP-488 dihydrochloride, TTP 488 dihydrochloride, Azeliragon hydrochloride, Azeliragon dihydrochloride
别名:TTP488 HCl, TTP-488 dihydrochloride, TTP 488 dihydrochloride, Azeliragon hydrochloride, Azeliragon dihydrochloride
IUPAC:[3-(4-{2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)propyl]diethylamine dihydrochloride
IUPAC:[3-(4-{2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl}phenoxy)propyl]diethylamine dihydrochloride
InChI key:CQAGJWKITXAOAM-UHFFFAOYSA-N

分子式:C32H40Cl3N3O2
分子量:605.04
氢键供体数 (HBD):0
氢键受体数 (HBA):3
LogP:8.221105
SMILES:Cl.Cl.CCCCc1nc(cn1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN(CC)CC)cc1
SMILES:Cl.Cl.CCCCc1nc(cn1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN(CC)CC)cc1

Azeliragon is a potent and orally active inhibitor of RAGE (receptor for advanced glycation endproducts), a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain.

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