Name: Ruboxistaurin mesylate
Rating: 5 (10 reviews)

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HIT ID:HIT212711790
Cas No:192050-59-2
常用名:Ruboxistaurin mesylate
别名:LY-333531 Mesylate, LY-333531, LY333531, LY 333531
别名:LY-333531 Mesylate, LY-333531, LY333531, LY 333531
IUPAC:(18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione; methanesulfonic acid
IUPAC:(18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione; methanesulfonic acid
InChI key:DUHQBKLTAVUXFF-FERBBOLQSA-N

分子式:C29H32N4O6S
分子量:564.66
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:2.9780278
SMILES:CS(O)(=O)=O.CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 |t:14|
SMILES:CS(O)(=O)=O.CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 |t:14|

Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.

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